Paterega Igor Petrovych

Laboratory chief, Candidate of Veterinary Sciences

Tел. (032) 252-92-07 


Main tasks of pharmacology and toxicology laboratory are improvement of maintenance methods, examination of action efficacy and development of new methods for studying of veterinary medicinal products and feed additives quality aiming at marketing in Ukraine of highly-effective antimicrobials, anthelmintics, anti-inflammatory and immune active products without mutagenic and side effects.

Sector of toxicological control – Zh.M. Perih
Vivarium – O.V. Farion

In vivarium all the conditions concerning keeping, feeding, conducting of tests are provided according to international ecological requirements, control over execution of rules of humane treatment of poultry, rabbits, guinea pigs, rats, mice. Aiming at reduced usage of laboratory and farming animals, alternative methods of toxicological experiments are developed and implemented, they aim at usage of infusoria, guppies, bees, drosophilas, culture cells of different tissues, buccal epithelium of guinea pigs by using modern equipments and conducting of new physiological tests.

Functions of laboratory:

  • Determination of conditions of test conducting using laboratory and farming animals;
  • Determination of acute toxicity;
  • Detection of cumulative peculiarities;
  • Determination of side effects;
  • Studying of chronic toxicity;
  • Detection of distant consequences;
  • Studying of acute and subacute toxicity of veterinary medicinal products, feeds and feed additives using farming animals;
  • Alternative control methods of toxicological tests;
  • Examination of quality and biological action of chemo medicinal products in induced experiments;
  • Preparation and conducting of preclinical and clinical tests;
  • Control over execution of rules of humane treatment of animals;
Test methods used by pharmacology and toxicology laboratory 
Preclinical toxicological tests
Studying of toxicity of substance and finished drug forms at single application (acute toxicity) to different types of laboratory animals by several routes of administration (in stomach, intravenously, subcutaneously). Durability of tests equals to 3 months.
Studying of toxicity of substance and finished drug forms at repeated application (subacute and acute toxicity) to 2-3 species of animals (white mice, white rats, rabbits) by different routes of administration recommended for clinical trials. Durability of tests, depending on durability of chronic experiment, equals to 6-12 months.
Studying of influence of medicinal products on reproduction ability: teratogenicity and gonadal toxicity. Durability of tests is equal to 10 months.
Evaluation of allergenic and immune modulating peculiarities. Durability of tests is equal to 6 months.
Studying of mutagenic peculiarities with predicting of cancinogenity that gives an opportunity to conduct clinical trials. Durability of tests is equal to 6 months.
Studying of cancinogenity by chronic experiments using different animals. Durability of tests is equal to 3,5 years.
Test of pharmacokinetics and bioavailability. Durability of tests is equal to 6 months.
Tests of medicinal products according to full-scale programme and preparation of appropriate documents for submission to Pharmacological group can take one year (excluding test on cancinogenity).